項目別分類　←　ここをクリック

[2016]

Islam MS, Horiguchi K, Iino S, Kaji N, Mikawa S, Hori M, Ozaki H.
Epidermal growth factor is a critical regulator of the cytokine IL-33 in intestinal epithelial cells. Br J Pharmacol. 2016 Aug;173(16):2532-42. doi: 10.1111/bph.13535. Epub 2016 Jul 19. PMID: 27300306

Kaji N, Horiguchi K, Iino S, Nakayama S, Ohwada T, Otani Y, Firman, Murata T, Sanders KM,
Ozaki H, Hori M. Nitric oxide-induced oxidative stress impairs pacemaker function of murine
interstitial cells of Cajal during inflammation. Pharmacol Res. 2016 Jul 25.
pii: S1043-6618(16)30224-9. doi: 10.1016/j.phrs.2016.07.030. [Epub ahead of print]. PMID: 27468647

[2015]

Ashina K, Tsubosaka Y, Nakamura T, Omori K, Kobayashi K, Hori M, Ozaki H, Murata T.
Histamine Induces Vascular Hyperpermeability by Increasing Blood Flow and Endothelial
Barrier Disruption In Vivo. PLoS One. 2015 Jul 9;10(7):e0132367. doi: 10.1371/journal.pone.0132367. eCollection 2015. PMID: 26158531

Mikawa S, Ohta Y, Kaji N, Islam MS, Murata T, Ozaki H, Hori M.
Time-dependent changes in inhibitory action of lipopolysaccharide on intestinal motility in rat. J Vet Med Sci. 2015 Jun 8. [Epub ahead of print] PMID: 26051129

Mikawa S, Yamamoto S, Islam MS, Kaji N, Murata T, Mizuno R, Ozaki H, Hori M.
Anti-emetic drug maropitant induces intestinal motility disorder but not anti-inflammatory action in mice.
J Vet Med Sci. 2015 May 3. [Epub ahead of print] PMID: 25947563

Maehara T, Matsumoto K, Horiguchi K, Kondo M, Iino S, Horie S, Murata T, Tsubone H, Shimada S,
Ozaki H, Hori M. Therapeutic action of 5-HT3 receptor antagonists targeting peritoneal macrophages in postoperative ileus. Br J Pharmacol. 2015 Feb;172(4):1136-47. doi: 10.1111/bph.13006.

[2014]

Tsubosaka Y, Nakamura T, Hirai H, Hori M, Nakamura M, Ozaki H, Murata T. (2014)
A Deficiency in the Prostaglandin D2 Receptor CRTH2 Exacerbates Adjuvant-Induced Joint Inflammation.
J Immunol. 2014 Dec 15;193(12):5835-40. doi: 10.4049/jimmunol.1303478.

Mori D, Watanabe N, Kaminuma O, Murata T, Hiroi T, Ozaki H, Hori M. (2014)
IL-17A induces hypo-contraction of intestinal smooth muscle via induction of iNOS in muscularis macrophages.
J Pharmacol Sci. 2014;125(4):394-405. Epub 2014 Jul 25. PMID: 25069526

Kobayashi K, Sato K, Kida T, Omori K, Hori M, Ozaki H, Murata T. (2014)
Stromal Cell-Derived Factor-1α/C-X-C Chemokine Receptor Type 4 Axis Promotes Endothelial Cell Barrier Integrity via Phosphoinositide 3-Kinase and Rac1 Activation.
Arterioscler Thromb Vasc Biol. 2014 Jun 12. pii: ATVBAHA.114.303890.

Omori K, Kida T, Hori M, Ozaki H, Murata T. (2014)
Multiple roles of prostaglandin E2 -EP signal in vascular permeability.
Br J Pharmacol. 2014 Jun 12. doi: 10.1111/bph.12815.

Iwanaga K, Nakamura T, Maeda S, Aritake K, Hori M, Urade Y, Ozaki H, Murata T.
Mast cell-derived prostaglandin d2 inhibits colitis and colitis-associated colon cancer in mice.
Cancer Res. 2014 Jun 1;74(11):3011-9. doi: 10.1158/0008-5472

Yamasaki, M., Iwase, M., Kawano, K., Sakakibara, Y., Suiko, M., Ikeda, M., Nishiyama, K. (2014)
Alpha Lipoic Acid supressed migration and invasion via downregulation of cell surface β1-integrin expression in badder cancer cells.
J. Clin. Biochem. Nutr 54, 18-25 10.3164/jcbn.13-57

Endo M, Hori M, Ozaki H, Oikawa T, Hanawa T.
Rikkunshito, a Kampo medicine, ameliorates post-operative ileus by anti-inflammatory action. J Pharmacol Sci. 2014;124(3):374-85.

Takahashi, S., Muta, K., Sonoda, H., Kato, A., Abdeen, A., Ikeda, M. (2014)
The role of cysteine 227 in subcellular localization, water permeability, and multimerization of aquaporin-11.
FEBS Open Bio　 doi.org/10.1016/j.fob.2014.03.005

Tanahashi Y, Ichimura Y, Kimura K, Matsuyama H, Iino S, Komori S, Unno T. (2014)
Cholinergic neuromuscular transmission mediated by interstitial cells of Cajal in the myenteric layer in mouse ileal longitudinal smooth muscles.
Naunyn Schmiedebergs Arch Pharmacol.387:377-388 DOI 10.1007/s00210-013-0944-2

Fujii T, Horiguchi K, Sunaga H, Moriwaki Y, Misawa H, Kasahara T, Tsuji S, Kawashima K (2014)
SLURP-1, an endogenous α7 nicotinic acetylcholine receptor allosteric ligand, is expressed in CD205+ dendritic cells in human tonsils and potentiates lymphocytic cholinergic activity.
J Neuroimmunol 267(1-2):43-49. 10.1016/j.jneuroim.2013.12.003

Sarashina H, Tsubosaka Y, Omori K, Aritake K, Nakagawa T, Hori M, Hirai H, Nakamura M, Narumiya S, Urade Y, Ozaki H, Murata T. (2014)
Opposing immunomodulatory roles of prostaglandin D2 during the progression of skin inflammation.
J Immunol Jan 1;192(1):459-65. 10.4049/jimmunol.1302080

Kida T, Omori K, Hori M, Ozaki H, Murata T. (2014)
Stimulation of G protein-coupled bile acid receptor enhances vascular endothelial barrier function via activation of protein kinase A and Rac1.
J Pharmacol Exp Ther Jan;348(1):125-30. 10.1124/jpet.113.209288

Islam MS, Kusakabe M, Horiguchi K, Iino S, Nakamura T, Iwanaga K, Hashimoto H, Matsumoto S, Murata T, Hori M, Ozaki H. (2014)
PDGF and TGF-β promote tenascin-C expression in subepithelial myofibroblasts and contribute to intestinal mucosal protection in mice.
Br J Pharmacol 171(2):375-88. 10.1111/bph.12452

Md Shafiqul Islam, Matsuki N, Nagasaka R, Ohara K, Hosoya T, Ozaki H, Ushio H, Hori, M. (2014)
Rice bran antioxidants in health and wellness.
In. Wheat and Rice in Disease Prevention and Health. Ed. Watson R.R. pp. 443-451. Academic Press, 2014

[2013]

Kawasaki H, Yoshida T, Horiguchi K, Ohama T, Sato K. (2013)
Characterization of Anoikis-Resistant Cells in Mouse Colonic Epithelium.
J Vet Med Sci 75(9):1173-1180.

Tanahashi Y, Waki N, Unno T, Matsuyama H, Iino S, Kitazawa T, Yamada M, Komori S. (2013)
Roles of M2 and M3 muscarinic receptors in the generation of rhythmic motor activity in mouse small intestine.
Neurogastroenterol Motil 25(10):e687-97. doi: 10.1111/nmo.12194

Habibul B. Shozib, Haruhiko Suzuki, Satoshi Iino, Shinsuke Nakayama (2013)
Acceleration of Ileal Pacemaker Activity in Mice Lacking Interleukin-10.
Inflammatory Bowel Diseases 19(8):1577-85 10.1097/MIB.0b013e31828eedf5
Kobayashi K, Tsubosaka Y, Hori M, Narumiya S, Ozaki H, Murata T (2013)
Prostaglandin D2-DP signaling promotes endothelial barrier function via the cAMP/PKA/Tiam1/Rac1 pathway.
Arterioscler Thromb Vasc Biol. 33(3):565-71 DOI:10.1161/ATVBAHA.112.300993

Iwanaga K, Murata T, Hori M, Ozaki H (2013)
Purinergic P2Y1 receptor signaling mediates wound stimuli-induced cyclooxygenase-2 expression in intestinal subepithelial myofibroblasts.
Eur J Pharmacol 702:158-164. DOI: 10.1016/j.ejphar.2013.01.025

Maeda S, Maeda S, Ohno K, Kaji N, Hori M, Fujino Y, Tsujimoto H (2013)
Protease-activated receptor-2 induces proinflammatory cytokine and chemokine gene expression in canine keratinocytes.
Vet Immunol Immunopathol 15;153:17-25. DOI: 10.1016/j.vetimm.2013.01.018

Murata T, Aritake K, Tsubosaka Y, Maruyama T, Nakagawa T, Hori M, Hirai H, Nakamura M, Narumiya S, Urade Y, Ozaki H (2013)
Anti-inflammatory role of PGD2 in acute lung inflammation and therapeutic application of its signal enhancement.
Proc Natl Acad Sci U S A. (2013) 110:5205-5210 DOI: 10.1073/pnas.1218091110

Ayabe S, Kida T, Hori M, Ozaki H, Murata T (2013)
Prostaglandin D2 Inhibits Collagen Secretion From Lung Fibroblasts by Activating the DP Receptor.
J Pharmacol Sci. (2013) 121(4):312-317 DOI: 10.1254/jphs.12275FP

Kida T, Tsubosaka Y, Hori M, Ozaki H, Murata T (2013)
Bile Acid Receptor TGR5 Agonism Induces NO Production and Reduces Monocyte Adhesion in Vascular Endothelial Cells.
Arterioscler Thromb Vasc Biol 33(7):1663-1669. DOI: 10.1161/ATVBAHA.113.301565

Kida T, Sawada K, Kobayashi K, Hori M, Ozaki H, Murata T (2013)
Diverse effects of prostaglandin E2 on vascular contractility.
Heart Vessels. (2013) In press DOI: 10.1007/s00380-013-0374-6

Endo M, Hori M, Ozaki H, Oikawa T, Hanawa T (2013)
Daikenchuto, a traditional Japanese herbal medicine, ameliorates postoperative ileus by anti-inflammatory action through nicotinic acetylcholine receptors.
J Gastroenterol. (2013) In press DOI: 10.1007/s00535-013-0854-6

Nakamura T, Murata T, Hori M, Ozaki H (2013)
UDP promotes intestinal epithelial migration via the P2Y6 receptor.
Br J Pharmacol. (2013) 170:883-892 DOI: 10.1111/bph.12334

 

項目別分類

細胞運動の分子メカニズム、情報伝達系（収縮、遊走、細胞接着など）

Time-dependent changes in inhibitory action of lipopolysaccharide on intestinal motility in rat. Mikawa S, Ohta Y, Kaji N, Islam MS, Murata T, Ozaki H, Hori M. J Vet Med Sci. 2015 Jun 8. [Epub ahead of print] PMID: 26051129 Anti-emetic drug maropitant induces intestinal motility disorder but not anti-inflammatory action in mice. Mikawa S, Yamamoto S, Islam MS, Kaji N, Murata T, Mizuno R, Ozaki H, Hori M. J Vet Med Sci. 2015 May 3. [Epub ahead of print] PMID: 25947563 Maehara T, Matsumoto K, Horiguchi K, Kondo M, Iino S, Horie S, Murata T, Tsubone H, Shimada S, Ozaki H, Hori M. (2015) Therapeutic action of 5-HT3 receptor antagonists targeting peritoneal macrophages in postoperative ileus. Br J Pharmacol. 2015 Feb;172(4):1136-47. doi: 10.1111/bph.13006.

Yamasaki, M., Iwase, M., Kawano, K., Sakakibara, Y., Suiko, M., Ikeda, M., Nishiyama, K. (2014) Alpha Lipoic Acid supressed migration and invasion via downregulation of cell surface β1-integrin expression in badder cancer cells. J. Clin. Biochem. Nutr 54, 18-25 10.3164/jcbn.13-57

Takahashi, S., Muta, K., Sonoda, H., Kato, A., Abdeen, A., Ikeda, M. (2014) The role of cysteine 227 in subcellular localization, water permeability, and multimerization of aquaporin-11. FEBS Open Bio　 doi.org/10.1016/j.fob.2014.03.005

Tanahashi Y, Ichimura Y, Kimura K, Matsuyama H, Iino S, Komori S, Unno T. (2014) Cholinergic neuromuscular transmission mediated by interstitial cells of Cajal in the myenteric layer in mouse ileal longitudinal smooth muscles. Naunyn Schmiedebergs Arch Pharmacol.387:377-388 DOI 10.1007/s00210-013-0944-2

Kida T, Omori K, Hori M, Ozaki H, Murata T. (2014) Stimulation of G protein-coupled bile acid receptor enhances vascular endothelial barrier function via activation of protein kinase A and Rac1. J Pharmacol Exp Ther Jan;348(1):125-30. 10.1124/jpet.113.209288

Islam MS, Kusakabe M, Horiguchi K, Iino S, Nakamura T, Iwanaga K, Hashimoto H, Matsumoto S, Murata T, Hori M, Ozaki H. (2014) PDGF and TGF-β promote tenascin-C expression in subepithelial myofibroblasts and contribute to intestinal mucosal protection in mice. Br J Pharmacol 171(2):375-88. 10.1111/bph.12452

Kawasaki H, Yoshida T, Horiguchi K, Ohama T, Sato K. (2013) Characterization of Anoikis-Resistant Cells in Mouse Colonic Epithelium. J Vet Med Sci 75(9):1173-1180.

Tanahashi Y, Waki N, Unno T, Matsuyama H, Iino S, Kitazawa T, Yamada M, Komori S. (2013) Roles of M2 and M3 muscarinic receptors in the generation of rhythmic motor activity in mouse small intestine. Neurogastroenterol Motil 25(10):e687-97. doi: 10.1111/nmo.12194

Iwanaga K, Murata T, Hori M, Ozaki H (2013) Purinergic P2Y1 receptor signaling mediates wound stimuli-induced cyclooxygenase-2 expression in intestinal subepithelial myofibroblasts. Eur J Pharmacol 702:158-164. DOI: 10.1016/j.ejphar.2013.01.025

Kida T, Tsubosaka Y, Hori M, Ozaki H, Murata T (2013) Bile Acid Receptor TGR5 Agonism Induces NO Production and Reduces Monocyte Adhesion in Vascular Endothelial Cells. Arterioscler Thromb Vasc Biol 33(7):1663-1669. DOI: 10.1161/ATVBAHA.113.301565

Nakamura T, Murata T, Hori M, Ozaki H (2013) UDP promotes intestinal epithelial migration via the P2Y6 receptor. Br J Pharmacol. (2013) 170:883-892 DOI: 10.1111/bph.12334

炎症応答からみた生理活性物質

Histamine Induces Vascular Hyperpermeability by Increasing Blood Flow and Endothelial Barrier Disruption In Vivo. Ashina K, Tsubosaka Y, Nakamura T, Omori K, Kobayashi K, Hori M, Ozaki H, Murata T. PLoS One. 2015 Jul 9;10(7):e0132367. doi: 10.1371/journal.pone.0132367. eCollection 2015. PMID: 26158531

Tsubosaka Y, Nakamura T, Hirai H, Hori M, Nakamura M, Ozaki H, Murata T. (2014) A Deficiency in the Prostaglandin D2 Receptor CRTH2 Exacerbates Adjuvant-Induced Joint Inflammation. J Immunol. Oct 31. pii: 1303478.

Kobayashi K, Sato K, Kida T, Omori K, Hori M, Ozaki H, Murata T. (2014) Stromal Cell-Derived Factor-1α/C-X-C Chemokine Receptor Type 4 Axis Promotes Endothelial Cell Barrier Integrity via Phosphoinositide 3-Kinase and Rac1 Activation. Arterioscler Thromb Vasc Biol. 2014 Jun 12. pii: ATVBAHA.114.303890.

Omori K, Kida T, Hori M, Ozaki H, Murata T. (2014) Multiple roles of prostaglandin E2 -EP signal in vascular permeability. Br J Pharmacol. 2014 Jun 12. doi: 10.1111/bph.12815.

Iwanaga K, Nakamura T, Maeda S, Aritake K, Hori M, Urade Y, Ozaki H, Murata T. Mast cell-derived prostaglandin d2 inhibits colitis and colitis-associated colon cancer in mice. Cancer Res. 2014 Jun 1;74(11):3011-9. doi: 10.1158/0008-5472

Habibul B. Shozib, Haruhiko Suzuki, Satoshi Iino, Shinsuke Nakayama (2013) Acceleration of Ileal Pacemaker Activity in Mice Lacking Interleukin-10. Inflammatory Bowel Diseases 19(8):1577-85 10.1097/MIB.0b013e31828eedf5 Kobayashi K, Tsubosaka Y, Hori M, Narumiya S, Ozaki H, Murata T (2013) Prostaglandin D2-DP signaling promotes endothelial barrier function via the cAMP/PKA/Tiam1/Rac1 pathway. Arterioscler Thromb Vasc Biol. 33(3):565-71 DOI:10.1161/ATVBAHA.112.300993

Murata T, Aritake K, Tsubosaka Y, Maruyama T, Nakagawa T, Hori M, Hirai H, Nakamura M, Narumiya S, Urade Y, Ozaki H (2013) Anti-inflammatory role of PGD2 in acute lung inflammation and therapeutic application of its signal enhancement. Proc Natl Acad Sci U S A. (2013) 110:5205-5210 DOI: 10.1073/pnas.1218091110

Ayabe S, Kida T, Hori M, Ozaki H, Murata T (2013) Prostaglandin D2 Inhibits Collagen Secretion From Lung Fibroblasts by Activating the DP Receptor. J Pharmacol Sci. (2013) 121(4):312-317 DOI: 10.1254/jphs.12275FP

Kida T, Sawada K, Kobayashi K, Hori M, Ozaki H, Murata T (2013) Diverse effects of prostaglandin E2 on vascular contractility. Heart Vessels. (2013) In press DOI: 10.1007/s00380-013-0374-6

免疫・炎症応答

Sarashina H, Tsubosaka Y, Omori K, Aritake K, Nakagawa T, Hori M, Hirai H, Nakamura M, Narumiya S, Urade Y, Ozaki H, Murata T. (2014) Opposing immunomodulatory roles of prostaglandin D2 during the progression of skin inflammation. J Immunol Jan 1;192(1):459-65. 10.4049/jimmunol.1302080

Fujii T, Horiguchi K, Sunaga H, Moriwaki Y, Misawa H, Kasahara T, Tsuji S, Kawashima K (2014) SLURP-1, an endogenous α7 nicotinic acetylcholine receptor allosteric ligand, is expressed in CD205+ dendritic cells in human tonsils and potentiates lymphocytic cholinergic activity. J Neuroimmunol 267(1-2):43-49. 10.1016/j.jneuroim.2013.12.003

Md Shafiqul Islam, Matsuki N, Nagasaka R, Ohara K, Hosoya T, Ozaki H, Ushio H, Hori, M. (2014) Rice bran antioxidants in health and wellness. In. Wheat and Rice in Disease Prevention and Health. Ed. Watson R.R. pp. 443-451. Academic Press, 2014

Maeda S, Maeda S, Ohno K, Kaji N, Hori M, Fujino Y, Tsujimoto H (2013) Protease-activated receptor-2 induces proinflammatory cytokine and chemokine gene expression in canine keratinocytes. Vet Immunol Immunopathol 15;153:17-25. DOI: 10.1016/j.vetimm.2013.01.018

平滑筋運動系の分子病態

Maehara T, Matsumoto K, Horiguchi K, Kondo M, Iino S, Horie S, Murata T, Tsubone H, Shimada S, Ozaki H, Hori M. (2014) Therapeutic action of 5-HT3 receptor antagonists targeting peritoneal macrophages in postoperative ileus. Br J Pharmacol. Nov 6. doi: 10.1111/bph.13006.

Mori D, Watanabe N, Kaminuma O, Murata T, Hiroi T, Ozaki H, Hori M. (2014) IL-17A induces hypo-contraction of intestinal smooth muscle via induction of iNOS in muscularis macrophages. J Pharmacol Sci. 2014;125(4):394-405. Epub 2014 Jul 25. PMID: 25069526

Endo M, Hori M, Ozaki H, Oikawa T, Hanawa T. (2014) Rikkunshito, a Kampo medicine, ameliorates post-operative ileus by anti-inflammatory action.J Pharmacol Sci. 2014;124(3):374-85.

Endo M, Hori M, Ozaki H, Oikawa T, Hanawa T (2013) Daikenchuto, a traditional Japanese herbal medicine, ameliorates postoperative ileus by anti-inflammatory action through nicotinic acetylcholine receptors. J Gastroenterol. (2013) In press DOI: 10.1007/s00535-013-0854-6

その他